University of Pavia
We build physiology through instrumented cells, tissue systems, CompBio, and the visual culture that helps make complex biology thinkable.
Lab vision
SPL treats engineering, computation, and visual culture as one experimental loop. We construct cells, tissues, models, and images that make physiology observable, testable, and open to revision.
We build cells that report on themselves. Fluorescent sensors, genetic reporters, lineage markers, and cell-cycle tools turn living human cells into readable systems, so state, function, and history can be measured while biology unfolds.
Physiology is not a single-cell property. We engineer matrices, confinement, geometry, organoid systems, and high-throughput tissue platforms to test how cells coordinate across space, mechanics, and time.
Complex experiments only become useful when their signals can be integrated. We combine bioimage analysis, mechanistic modeling, and computational inference to connect morphology, dynamics, reporters, and physical context into coherent biological readouts.
Scientific imagination is visual, material, and human. We use illustration, design, and visual culture as part of the research process: to make hypotheses concrete, expose hidden structure, and communicate complex systems without flattening them.
Funded work
Unlocking the data content of Organ-on-Chips
Instrumented human stem cells to see more during high-throughput screening
REsolving infections by modulating SEnescenT macrophages
All-Optical Engineering of Human Tissue Models for Ultra High-Throughput Drug Screening
Engineered in-vitro and in-silico models of cardiometabolic diseases to screen DNA/RNA-based therapeutics
A competence center for bio/nano-sustainability
Synthetic Matrix Biology: Designer matrices to program healthy and diseased myocardial morphogenesis