Synthetic Physiology Lab

Research

Publications.

SPL publications, newest first, followed by selected pre-SPL work from the PI’s time at the Wyss Zurich Translational Center (University of Zurich and ETH Zurich).

Highlighted papers

Our recent work at SPL and with collaborators.

Five papers chosen to represent our work across computational modeling, engineered tissues, live imaging, and bioimage analysis.

Peer-reviewed article SPL CALIPERS: Cell cycle-aware live imaging for phenotyping experiments and regeneration studies Nature Communications · 2026 · DOI 10.1038/s41467-026-76144-9 Peer-reviewed article SPL MicroSplit: semantic unmixing of fluorescent microscopy data Nature Methods · 2026 · DOI 10.1038/s41592-026-03082-1 Peer-reviewed article SPL Micro-comb 3D printing: rapid fabrication of tissue-guiding substrates using micro-embossed nozzles Biofabrication · 2026 · DOI 10.1088/1758-5090/ae5fd9 Peer-reviewed article SPL BIOPOINT: A particle-based model for probing nuclear mechanics and cell-ECM interactions via experimentally derived parameters PLOS Computational Biology · 2026 · DOI 10.1371/journal.pcbi.1014113 Peer-reviewed article SPL Fabrication of cell culture hydrogels by robotic liquid handling automation for high-throughput drug testing Communications Engineering · 2025 · DOI 10.1038/s44172-025-00575-3

Complete record

All publications.

Peer-reviewed article SPL

MicroSplit: semantic unmixing of fluorescent microscopy data

Ashesh Ashesh, Federico Carrara, Igor Zubarev, Vera Galinova, Melisande Croft, Melissa Pezzotti, Daozheng Gong, Francesca Casagrande, Elisa Colombo, Stefania Giussani, Elena Restelli, Eugenia Cammarota, Juan Manuel Battagliotti, Nikolai Klena, Moises Di Sante, Raghabendra Adhikari, Daniel Feliciano, Gaia Pigino, Elena Taverna, Oliver Harschnitz, Nicola Maghelli, Norbert Scherer, Damian Edward Dalle Nogare, Joran Deschamps, Francesco Pasqualini, Florian Jug

Nature Methods · 2026 · DOI 10.1038/s41592-026-03082-1

Peer-reviewed article pre-SPL

A tissue-engineered scale model of the heart ventricle

Luke A MacQueen, Sean P Sheehy, Christophe O Chantre, John F Zimmerman, Francesco S Pasqualini, Xujie Liu, Josue A Goss, Patrick H Campbell, Grant M Gonzalez, Sung-Jin Park, Andrew K Capulli, John P Ferrier, T Fettah Kosar, L Mahadevan, William T Pu, Kevin Kit Parker

Nature Biomedical Engineering · 2018 · DOI 10.1038/s41551-018-0271-5

Peer-reviewed article pre-SPL

Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - From cardioprotection to functional repair in a translational pig infarction model

Emmert MY, Wolint P, Jakab A, Sheehy SP, Pasqualini FS, Nguyen TDL, Hilbe M, Seifert B, Weber B, Brokopp CE, Macejovska D, Caliskan E, von Eckardstein A, Schwartlander R, Vogel V, Falk V, Parker KK, Gyongyosi M, Hoerstrup SP

Biomaterials · 2017 · DOI 10.1016/j.biomaterials.2016.11.029

Peer-reviewed article pre-SPL

Phototactic guidance of a tissue-engineered soft-robotic ray

Sung-Jin Park, Mattia Gazzola, Kyung Soo Park, Shirley Park, Valentina Di Santo, Erin L Blevins, Johan U Lind, Patrick H Campbell, Stephanie Dauth, Andrew K Capulli, Francesco S Pasqualini, Seungkuk Ahn, Alexander Cho, Hongyan Yuan, Ben M Maoz, Ragu Vijaykumar, Jeong-Woo Choi, Karl Deisseroth, George V Lauder, L Mahadevan, Kevin Kit Parker

Science · 2016 · DOI 10.1126/science.aaf4292